Proceedings of APCE-CECE-ITP-IUPAC 2022

In a demonstration of modern analytical chemistry at its best, the International Inter-disciplinary Conference of Chemical Analysis, APCE-CECE-ITP-IUPAC 2022 was held after two years of COVID-19-related delays in Siem Reap, Cambodia. The quadruple meeting included: 18th Asia Pacific International Symposium on Microscale Separations and Analyses, 17th International Interdisciplinary Meeting on Bioanalysis, 28th International Symposium on Electro-and Liquid Phase-Separation Techniques, and IUPAC Special Symposia by Division of Chemistry and the Environment. While, under normal circumstances, these conferences would take place in different countries, we have decided to bring together analytical chemists from all over the world for a conference covering all aspects of modern analytical chemistry. Our goal remained the same: bring together scientists from different disciplines who may not meet at other meetings. With plenary and invited lectures delivered by distinguished scientists, this in-person meeting allowed to broaden our knowledge, meet new friends, and start new collaborations. The organizers want to thank all speakers, sponsors, and participants for their support. Please, check the conference web for more information about the history, programs, photos, and videos.

Microporous Matrimid/PIM-1 Thin Film Composite Membranes with Narrow Pore Size Distribution used for Molecular Separation in Organic Solvents.

Polymers of intrinsic microporosity (PIMs) are a class of microporous organic materials that contain interconnected pores of less than 2 nm in diameter. Such materials are of great potential used in membranes for molecular separation, such as drug fractionation in pharmaceutical industry. However, the PIMs membranes are often susceptible to low separation selectivity toward different molecules due to their wide pore size distribution. Herein, a linear polyimide, Matrimid, is incorporated with PIM-1 (a typical member of PIMs) by solution blending, and the blends are dip-coated onto a polyimide P84 support membrane to prepare thin-film composite (TFC) membranes to control pore size distribution while keep high microporosity. The component miscibility, pore characteristics, and molecular separation performances of the Matrimid/PIM-1 TFC membranes are investigated in detail. The Matrimid and PIM-1 are partially miscible due to their similar Hansen solubility parameters. The Matrimid endows the selective layers (coatings) with narrower pore size distribution due to more compact chain packing. The prepared Matrimid/PIM-1 TFC membranes show high selectivity for separation of riboflavin (80% of retention) and isatin (only 5% of retention). The developed membranes exhibit great potential for separating molecules with different molecular weights.

Employer reallocation during the COVID-19 pandemic: Validation and application of a do-it-yourself CPS.

Economists have recently begun using independent online surveys to collect national labor market data. Questions remain over the quality of such data. This paper provides an approach to address these concerns. Our case study is the Real-Time Population Survey (RPS), a novel online survey of the US built around the Current Population Survey (CPS). The RPS replicates core components of the CPS, ensuring comparable measures that allow us to weight and rigorously validate our results using a high-quality benchmark. At the same time, special questions in the RPS yield novel information regarding employer reallocation during the COVID-19 pandemic. We estimate that 26% of pre-pandemic workers were working for a new employer one year into the COVID-19 outbreak in the US, at least double the rate of any previous episode in the past quarter century. Our discussion contains practical suggestions for the design of novel labor market surveys and highlights other promising applications of our methodology.

The heterogeneous effects of COVID-19 on labor market flows: evidence from administrative data.

We investigate the short-term effects of COVID-19 on labor market flows and how they are mediated by labor market policy. Using Italian administrative data on a sample of active contracts between 2009 and the second quarter of 2020, we show that, before the pandemic, a higher share of female compared to male, young compared to old and low educated compared to high educated workers is employed in non-essential activities. When we look at the change in hirings and separations, from the 9th week of 2020 - the time when first cases and deaths due to COVID-19 were recorded -, we find a pronounced drop in hirings and endings of fixed-term contracts. Layoffs and quits increase after the 9th week, and then decline significantly, reflecting the effects of government intervention. The lifting of the lockdown triggers a slow recovery of labor market flows. Young workers, those on temporary contracts, low-educated workers, those employed in the South and those with no opportunities of working from home experience a greater decline in separation probability, indicating that government policy partly protected them from the labor market impact of the recession. The decline in the separation probability for women is lower than that for men. Supplementary Information: The online version contains supplementary material available at 10.1007/s10888-021-09522-610.1007/s10888-021-09522-6.

Wages and labor market flows in times of the corona crisis

The paper discusses two major dimensions of labor market adjustment to crisis conditions in Russia in 2020. Price adjustment manifests itself through changes in wages, and quantitative adjustment - in hiring and separations. Most general conclusion is that, in 2020, the former dominated, while the latter also took place. Our analysis shows deep but very selective and short run fall in wages. Exposure to downward wage flexibility was a function of type of economic activity and type of residence, not of demographic characteristics or education. Freezing new hires became the main instrument for quantitative adjustment, though the intensity of separations decreased as well. Reduction in both components of labor turnover means slower workers' reallocation and preservation of the old economic structure. If during the previous crises legislative and administrative measures slowed down reductions in personnel, which could be beneficial for employers, in the covid case employers seek to preserve the matching capital needed for fast and efficient recovery and growth.

Sample Preparation and Diagnostic Methods for a Variety of Settings: A Comprehensive Review.

Sample preparation is an essential step for nearly every type of biochemical analysis in use today. Among the most important of these analyses is the diagnosis of diseases, since their treatment may rely greatly on time and, in the case of infectious diseases, containing their spread within a population to prevent outbreaks. To address this, many different methods have been developed for use in the wide variety of settings for which they are needed. In this work, we have reviewed the literature and report on a broad range of methods that have been developed in recent years and their applications to point-of-care (POC), high-throughput screening, and low-resource and traditional clinical settings for diagnosis, including some of those that were developed in response to the coronavirus disease 2019 (COVID-19) pandemic. In addition to covering alternative approaches and improvements to traditional sample preparation techniques such as extractions and separations, techniques that have been developed with focuses on integration with smart devices, laboratory automation, and biosensors are also discussed.

Update on Proteomic approaches to uncovering virus-induced protein alterations and virus -host protein interactions during the progression of viral infection.

INTRODUCTION: Viruses induce profound changes in the cells they infect. Understanding these perturbations will assist in designing better therapeutics to combat viral infection. System-based proteomic assays now provide unprecedented opportunity to monitor large numbers of cellular proteins. AREAS COVERED: This review will describe various quantitative and functional mass spectrometry-based methods, and complementary non-mass spectrometry-based methods, such as aptamer profiling and proximity extension assays, and examples of how each are used to delineate how viruses affect host cells, identify which viral proteins interact with which cellular proteins, and how these change during the course of a viral infection. PubMed was searched multiple times prior to manuscript submissions and revisions, using virus, viral, proteomics; in combination with each keyword. The most recent examples of published works from each search were then analyzed. EXPERT OPINION: There has been exponential growth in numbers and types of proteomic analyses in recent years. Continued development of reagents that allow increased multiplexing and deeper proteomic probing of the cell, at quantitative and functional levels, enhancements that target more important protein modifications, and improved bioinformatics software tools and pathway prediction algorithms will accelerate this growth and usher in a new era of host proteome understanding.